The altered function or expression of these proteins lead to various diseases, such as pseudoxanthoma elasticum, cystic fibrosis, diabetes mellitus type II, adrenoleukodystrophy, etc. We aim to understand the molecular level processes resulting in ABC associated disorders and design strategies to overcome the effect of the altered functional state of ABC proteins.

To prevent our being in a state of permanent uncertainty about the powers of the mind, and to prevent our mental labours being misguided and haphazard, we ought once in our life carefully to inquire as to what sort of knowledge human reason is capable of attaining, before we set about acquiring knowledge of things in particular. Singer and Magee on Hegel and Marx.